Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers

Background: Diagnosis of sepsis in burn patients remains difficult for various reasons. One major problem is the definition itself. Therefore, previous and current definitions are a matter ongoing validation, but well-defined consensus on which clinical laboratory parameters to incorporate such lacking. The aim present study was compare incidence time-related occurrence septic events according different as well their accompanying time course pro-inflammatory biomarkers. Methods: Across first 14 days after admission, point three (Sepsis-3, Sepsis American Burns Association [ABA] 2007, Zurich Burn Center) were assessed daily basis adult with total body surface area (TBSA) ≥15% admitted Center between May 2015 October 2018. In order investigate how drawn proinflammatory biomarkers (white blood cells (WBCs), C-reactive protein (CRP), procalcitonin (PCT), novel pancreatic stone (PSP)) reflect progression depending its type definition, longitudinal mixed model analysis performed across non-septic patients. Additionally, relative increase biomarker levels 24, 48, 72 h prior event analyzed each used. Results: our cohort 90 severely burned patients, Sepsis-3 identified 46 (51.1%) septic, while ABA 2007 counted 33 (36.7%) 24 (26.6%), respectively. detected about 1 day earlier than (p < 0.001) 0.5 = 0.04). largely unaffected by definition. Irrespective PSP only marker demonstrate highly significant interaction group (sepsis versus no sepsis) 3.3–5.5-fold within before sepsis, whereas CRP, PCT, WBC showed mild undulations. Conclusions: Despite dilemma define continually calculated SOFA score used advantageous early identify patient’s detrimental sepsis. Inclusion biomarkers, PSP, may help support specialist’s diagnosis could improve diagnostic performance future